Description

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B). Receptor for the cytotoxic ligand TNFSF10/TRAIL. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.


Clinical trials

NCT03638206 - Colorectal Cancer, Esophagus Cancer, Renal Carcinoma, Hepatoma, Lung Cancer, Mesothelioma, Ovarian Cancer, Pancreatic Cancer, Melanoma


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene TNFRSF10B.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present.