Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B). Receptor for the cytotoxic ligand TNFSF10/TRAIL. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
NCT03638206 - Colorectal Cancer, Esophagus Cancer, Renal Carcinoma, Hepatoma, Lung Cancer, Mesothelioma, Ovarian Cancer, Pancreatic Cancer, Melanoma
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present.